基于共价有机框架的仿生光动力学治疗试剂的构建

共价有机框架（COF）是一类新兴的多孔有机聚合物，因其具有较大的比表面积、有序的孔道结构以及良好的生物相容性，已成为具有潜力的纳米药物载体.制备了基于COF纳米颗粒的仿生纳米复合物，负载光敏剂孟加拉玫瑰红（RB），并包裹癌细胞膜（CMV）对该复合物进行仿生修饰.结果表明：制备的COF/RB@CMV纳米复合物具有良好的生物兼容性，能够被肿瘤细胞有效摄取，并在光照激活条件下产生对细胞具有高毒性的活性氧化物（ROS），进而起到了杀伤肿瘤细胞的作用.提出了一种新的基于COF的仿生纳米平台用作光动力学治疗（PDT）试剂.     

无环境信息下多尺度网格细胞群空间表征模型

针对无环境信息条件下网格细胞空间表征问题, 提出一种多尺度网格细胞群的空间表征模型。通过减少吸引子网络模型网格细胞的偏好朝向, 使网格细胞具有特定的感应方向, 仅对特定方向上的速度产生响应。基于改进的吸引子网络模型, 构建多尺度网格细胞群, 并对空间进行表征。仿真结果表明, 改进后的网格细胞模型只响应相应方向的速度, 准确整合速度信息, 表征部分未探索区域, 且适用于无环境信息条件下一维、二维空间。在100 m×100 m的区域, 表征结果的误差不超过0.2 m, 证明了该模型能够扩大网格细胞的表征范围, 提高表征精度与表征能力。     

2020年细胞力学热点回眸

 概述了2020年细胞力学研究的热点和进展，探讨了细胞膜表面张力、细胞粘附力、细胞弹性模量、细胞与纳米颗粒相对刚度等对细胞生物学行为的影响及其在疾病诊疗中的应用。     

基于CRC的ASM信号维特比纠错算法

为提高甚高频数据交换系统(very high frequency data exchange system, VDES)中应用特定消息(application-specific messages, ASM)的解码性能, 提出一种基于循环冗余校验(cyclic redundancy check, CRC)的改进维特比纠错算法。通过合理降低符号状态数和使用部分CRC参与纠错, 使该算法平衡了纠错性能和计算量, 同时提出了新的分支度量以解决过于理想化的传统分支度量导致的性能损失。仿真表明, 新分支度量相比传统分支度量提升了1 dB的误帧率(packet error rate, PER)性能, 在用12个CRC寄存器参与纠错的条件下，该方法比相干解调算法提升了1 dB的PER性能, 同时通过合理的符号状态数降低策略将计算量降为传统算法的1/4。     

电动汽车替代燃油车的气候和健康影响及社会成本——基于单车视角的成本效益分析

构建基于能源周期和全生命周期的分析框架, 借助基于概率分布的成本效益分析方法, 通过评估单辆纯电动汽车替代汽油车的气候和健康影响及相关社会成本, 探讨现阶段电动汽车替代传统燃油车能否实现气候、健康和社会福利的改进。研究结果表明, 在现有技术条件和电厂超低排放改造背景下, 尽管电动汽车替代传统燃油车在能源周期能够实现碳减排(约324元/(辆^.年))、健康损害降低(约343元/(辆^.年))以及可观的能源节约(约4315元/(辆^.年)), 但由于两种车辆之间巨大的制造成本差异(约1.6万元/(辆^.年)), 现阶段电动汽车对传统燃油车的全面替代并不能实现社会总体福利的改进。因此, 中国电动汽车推广政策短期内不应以全面替代为目标, 而应识别具有较高气候和健康效益以及具有较大能源节约潜力的区域优先推广。     

Google Trends and the forecasting performance of exchange rate models

In this paper, we use Google Trends data for exchange rate forecasting in the context of a broad literature review that ties the exchange rate movements with macroeconomic fundamentals. The sample covers 11 OECD countries’ exchange rates for the period from January 2004 to June 2014. In out‐of‐sample forecasting of monthly returns on exchange rates, our findings indicate that the Google Trends search query data do a better job than the structural models in predicting the true direction of changes in nominal exchange rates. We also observed that Google Trends‐based forecasts are better at picking up the direction of the changes in the monthly nominal exchange rates after the Great Recession era (2008–2009). Based on the Clark and West inference procedure of equal predictive accuracy testing, we found that the relative performance of Google Trends‐based exchange rate predictions against the null of a random walk model is no worse than the purchasing power parity model. On the other hand, although the monetary model fundamentals could beat the random walk null only in one out of 11 currency pairs, with Google Trends predictors we found evidence of better performance for five currency pairs. We believe that these findings necessitate further research in this area to investigate the extravalue one can get from Google search query data.     

Exchange rate forecasting and the performance of currency portfolios

We examine the potential gains of using exchange rate forecast models and forecast combination methods in the management of currency portfolios for three exchange rates: the euro versus the US dollar, the British pound, and the Japanese yen. We use a battery of econometric specifications to evaluate whether optimal currency portfolios implied by trading strategies based on exchange rate forecasts outperform single currencies and the equally weighted portfolio. We assess the differences in profitability of optimal currency portfolios for different types of investor preferences, two trading strategies, mean squared error‐based composite forecasts, and different forecast horizons. Our results indicate that there are clear benefits of integrating exchange rate forecasts from state‐of‐the‐art econometric models in currency portfolios. These benefits vary across investor preferences and prediction horizons but are rather similar across trading strategies.     

外汇欧式期权在市场不完备下的对冲误差分析

本文研究了外汇欧式期权的对冲误差问题,针对典型的静态和动态Delta对冲策略,在对冲过程不连续和利率平价公式不成立的市场不完备情形下,给出了即期对冲和远期对冲的对冲误差公式,从而能够更准确地衡量实际对冲组合产生的风险.在研究Delta对冲策略过程中,本文提出了一个包含摩擦系数ε的外汇远期汇率模型,并通过分析即期对冲和远期对冲的差异,给出了最优对冲方式的判别条件.该判别条件依赖于摩擦系数ε,做市商仅通过对摩擦系数ε实时的监控,便可以选择最优的风险对冲方式,从而提高了对冲效率.本文提出的对冲误差的具体解析式和最优对冲方式的判别条件为外汇期权对冲及其风险管理提供了理论依据.实证结果表明,本文提出的期望收益差与实际对冲组合的收益差基本一致,从而验证了判别条件的合理性.     

Key technologies for polymer electrolyte membrane fuel cell systems fueled impure hydrogen

Hydrogen energy and polymer electrolyte membrane (PEM) fuel cells become concerned issues in recent years. Nevertheless, the construction of hydrogen refueling infrastructure and hydrogen storage and transportation constrains the commercial development of fuel cells. In this review, sources, production, storage, transportation, and purification methods of hydrogen are extensively reviewed and compared. The advantages of utilizing industrial by-product hydrogen and steam reforming gas in PEM fuel cell systems are analyzed. Using industrial wasted hydrogen can significantly reduce the cost of hydrogen. Also, it is indicated that the onboard hydrogen generation by steam methanol reforming can solve the difficulties of efficient storage and transportation of gaseous hydrogen, which means that methanol has great potential to be a convenient carrier of hydrogen. The effects of impurities contained in the reformate gas are generally introduced. After the methanol steam reforming and pretreatment purification processes, the reformate gas can be fed to PEM fuel cells. Thus, a fuel cell system integrated with onboard hydrogen production and impure hydrogen treatment subsystems is introduced, and key technologies therein for pretreatment purification and in-situ poisoning mitigation methods are reviewed. Finally, suggestions are proposed for further studies.     

Janus few layered graphene with asymmetric wettability as anti-flooding cathode supports in proton exchange membrane fuel cells

Water balance in cathode catalyst layer (CCL) is crucial for proton exchange membrane fuel cells (PEMFCs). Herein, we report a novel strategy to develop a Janus few layered graphene particles (FLGP) with asymmetric wettability by varying the carbon precursors in the chemical vapor deposition (CVD) process. Using the Janus FLGP supported Pt with asymmetric wettability as the cathode of a PEMFC, a peak power density of 632 mW cm⁻² was achieved, which was about two-folds of the hydrophobic FLGP and three-folds of hydrophilic FLGP based cathode, respectively. The enhanced performance could be ascribed to the well-constructed three-phase boundary in an anti-flooding cathode, leading to enlarged electrochemical active surface area and facilitated mass transfer. This work may provide new clues for improving water management in PEMFCs.